Thorpe reaction

The Thorpe reaction is a chemical reaction described as a self-condensation of aliphatic nitriles catalyzed by base to form enamines.^[1][2][3] The reaction was discovered by Jocelyn Field Thorpe.

Thorpe–Ziegler reaction

The Thorpe–Ziegler reaction (named after Jocelyn Field Thorpe and Karl Ziegler), or Ziegler method, is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation.

External links

• Thorpe-Ziegler reaction: 4-Phosphorinanone, 1-phenyl- Organic Syntheses, Coll. Vol. 6, p.932 (1988); Vol. 53, p.98 (1973) Link

References

1. ^ Baron, H.; Remfry, F. G. P.; Thorpe, Y. F. J. Chem. Soc. 1904, 85, 1726.
2. ^ Karl Ziegler et al. Ann. 1933, 504, 94.
3. ^ Schaefer, J. P.; Bloomfield, J. J. Org. React. 1967, 15, 1. (Review)